The most common cause of peripheral neuropathy is diabetes.
High blood sugar levels causes damage to the walls of the tiny blood vessels that supply oxygen and nutrients to the nerves in the ends of the hands and feet, and the essential organs in the body (eyes, kidneys, heart).
As a result, skin becomes damaged and the loss of sensation only makes the skin of the feet more prone to damage.
In the US, diabetic neuropathy is the primary cause of diabetic foot problems and ulcers. Specific estimates vary, but overall about half of people with diabetes have diabetic neuropathy